Over the past several years, there's been a growing movement of "citizen science" and a handful of related games which send data back to scientists to assist in various areas of work, including primarily genetics. Googling for "games" and "citizen science" will bring back some interesting possibilities for you. Many should be integrateable into a big history program, particularly the genetics related ones which explore some of the evolutionary related space along with curricula in biology, chemistry, and physics. In particular, students may be able to experience first hand how physics influences evolution in the mid-level thresholds from the start of life onwards.
Here's a particular example that was recently in Scientific American: http:/