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Role of Clinical Studies for Pets with Naturally Occurring Tumors in Translational Cancer Research | @NASciences http://www.nap.edu/catalog/21830/the-role-of-clinical-studies-for-pets-with-naturally-occurring-tumors-in-translational-cancer-research

 

Role of Clinical Studies for Pets with Naturally Occurring Tumors in Translational Cancer Research | @NASciences http://www.nap.edu/catalog/21830/the-role-of-clinical-studies-for-pets-with-naturally-occurring-tumors-in-translational-cancer-research

 

Reproducibility Issues in Research with Animals and Animal Models: Workshop in Brief | National Academies Press http://www.nap.edu/catalog/21835/reproducibility-issues-in-research-with-animals-and-animal-models-workshop

 

This popped up a few weeks ago in my little free library, and expecting that it fell into a similar category as my friend P.M. Forni's works, I thought I'd give it a quick read. Given the title, it certainly wasn't being marketed to me directly, but I suspect the writer lost the battle with the publisher for giving it a more sophisticated subtitle.

In particular, it comes out in the category of books fashioned from tying together ideas from a commonplace book(s). It's well written and covers a broad variety of ideas and research, which most are unlikely to be aware.

It's a bit more prescriptive and accessible to most in comparison to [book:Thinking, Fast and Slow|11468377], though I prefer the later for its depth. I was somewhat disappointed that her references were primarily from writers living after the 1400's while I initially expected to see more material from 400 BCE to 500AD, but one can obtain many of these from the aforementioned [author:P.M. Forni|148299] references. I was disappointed that her one passing mention of <i>eudaimonia</i> was for its simple existence as a word rather than for its relation to the thesis of the overarching text.

Having read many of her references including having been a fan and proponent of Benjamin Franklin's system for several decades, I didn't learn too many ideas I wasn't previously aware of, though it did make for a relatively interesting biography, in great part because of a large overlap in my interests and the author's.

I ran across many poor reviews of the work which seemed to focus on the writer's privileged background and her choice to write on this particular topic. I find this generally disingenuous as I seriously doubt any of these critics would have leveled similar barbs at any of the better known philosophers from ancient Greece onward and every one of those authors also held positions of power, prestige, and/or wealth. The real difference between the groups of writers is that this is a meta-analysis and general recipe for a modern approach to happiness while prior efforts by the classical writers were generally of a more straightforward philosophical bent.

I wasn't a fan of the inserted comments from the author's blog as a general narrative construct, though they did serve to provide additional ideas outside of the direct sphere of the author's experience to give unimaginative readers ideas about how they could use the advice to structure their own program.

As very few are aware of and even fewer have tried to implement Franklin's system, I could easily recommend this to a variety of people, though given the title and the marketing viewpoint of the book, I'm not sure many would take the content as seriously as they ought. I would rarely read, much less recommend a "self-help" title, but though I wish the references to the science of happiness were more thorough here there is some great underlying scientific material, so I would recommend this to anyone who wants to contempalate how to live a happier life.

 

Paul, thanks for the provocative piece, though the state of the art is certain much further along that your piece intimates. For the general reader, I would suggest reading MIT professor Cesar Hidalgo's recent book Why Information Grows (MIT Press, 2015) for some general structure and philosophy.

One of the best definitions and frameworks I've seen thus far has to be that of Christoph Adami. To start, and depending on your level of sophistication, take a look at his recent arXiv paper (Information-theoretic considerations concerning the origin of life - http://arxiv.org/abs/1409.0590 ) and then take a crack at this popular press article about it in Medium https://medium.com/the-physics-arxiv-blog/information-theory-and-the-origin-of-life-4cf6b93d156c). If it's something that blows your skirt up, then you can certainly begin to delve more deeply into some of his journal articles over the past decade or so.

For further references, I maintain a nice list of resources at Information Theory and Biology Resources [http://boffosocko.com/itbio/], as well as a "journal club" of sorts at Mendeley: ITBio: Information Theory, Microbiology, Evolution, and Complexity [https://www.mendeley.com/groups/2545131/itbio-information-theory-microbiology-evolution-and-complexity/].

For those who like to watch video material, I'll refer them to some videos from the NIMBioS Workshop on Information and Entropy in Biological Systems [http://boffosocko.com/2015/05/20/videos-from-nimbios-workshop-on-information-and-entropy-in-biological-systems/] organized by physicist John Carlos Baez. The Banff International Research Station also hosted a relatively recent week long workshop on Biological and Bio-Inspired Information Theory [http://www.birs.ca/events/2014/5-day-workshops/14w5170] which covered some interesting related ground with videos of many of the talks there as well.

 

The reply to site won't be visible to most as it was a private message, but someone asked about how to get started on building their own Little Free Library branch. My reply:

I wrote a little bit about my building process here: http://lfl8424.boffosocko.com/our-story-history-and-building-process/

You can find most of the details for set up and registry on http://www.littlefreelibrary.org. (They actually just updated their website over the weekend.) They have libraries that you can buy and they'll ship to you, though part of the movement is encouraging people to be creative in building and designing their own. I'm happy to help give you some ideas if you need the help, but their website and examples they have on their Facebook & Pinterest sites will surely help too. Visiting a few in the Glendale & Pasadena Areas might help as well - you can find a map at http://littlefreelibrary.org/ourmap/. I notice that several of the Glendale City LFL's aren't on the map, but can be found by googling "Glendale" and "Little Free Library" where you'll find the city's Library, Art and Culture page with addresses for all of them. There are several at nearby city parks as well as at city hall.

There's also a nice little book about building and hosting your own as well. You can find it on Amazon at http://amzn.to/1gtCPKP

The BookCrossing.com and GoodReads.com portion I've integrated into mine are unrelated websites that are used for releasing and tracking books out in the wild, but that both work with the LFL concept really well.

I've done a lot of research on the upfront side, so I do know quite a lot about the overall concepts, but obviously have only just opened my own. I'm happy to provide as much or as little help as you might need, just let me know.

Best,
Chris

 

Category Theory certainly isn't useless, and has some really beautiful and interesting things going on. One of the bigger issues it has is that it is relatively so young as a discipline within math. (Imagine what people said about set theory in 1910.) Your toughest hurdle as an undergraduate is finding a university that is offering it as an accessible class depending on your level of mathematical background. I haven't noticed a lot of universities even offering it at the graduate level yet either.

That being said, David Spivak's new book Category Theory for the Sciences which came out of MIT Press last year is the closest textbook I've seen to attempt making Category Theory easily accessible to not only an undergraduate audience, but also to a broader range of scientists who are not necessarily steeped in mathematics. For your particular purposes, it actually has a nice handful of biology related examples in the early chapters.

Because it expounds on some of the beauty of category theory and it's application to science, I'll draw your attention to an essay that Ilyas Khan wrote recently: https://www.linkedin.com/pulse/category-theory-bedrock-mathematics-ilyas-khan

I'd recommend category theory more highly, if you plan on pursuing a Ph.D. and research work, but in the meanwhile you might also find some interesting material in John Carlos Baez's Azimuth blog or on the n-Category Cafe.

 
 

Jef Rouner I suspect it's more likely the Kathryn Schultz photo that leads off the piece and not taking the time to research the factual answer, but that's just an opinion. With those who can't distinguish fact, you really never can tell. But thanks for philosophically breaking C.P. Snow's "Two Cultures" into The Three Cultures!

 

My answer to Question on @Quora: Would it be worth it to study category theory? http://qr.ae/R7u9ME

The sad answer for most in your situation is: probably not yet. There just isn't a broad layer of applied use of category theory in your area yet. (I'll note that I'm also an electrical engineer with a background in information theory.) HOWEVER, this certainly doesn't mean it's not important and that the future won't find lots of applications for it, particularly given its abstraction and ability to connect disparate areas of mathematics. On the bleeding edge of research, however, it's another story. (For a flavor of some of this, take a look at John Baez's blog Azimuth: https://johncarlosbaez.wordpress.com/?s=category+theory). Given my diverse mathematical background, I have no doubt that category theory will be exceedingly important over the next century, and particularly in the area of communications.

My suggestion to you, particularly as you mention that it seems very abstract, is that you do some preliminary background work in abstract algebra, combinatorics, and even set theory, which will likely be much more immediately applicable to your present area of study. These will give you a far better preparation for attacking category theory in the future. (I can't recall having seen or heard any EE departments even suggesting category theory courses recently, much less requiring them, even at the master's level. Further, very few universities are offering coursework directly in the topic at the moment, so it's far more likely that you'll only see it at the graduate level.

Those looking to dip their feet in the water might consider taking a look at How to Bake Pi: An Edible Exploration of the Mathematics of Mathematics by Eugenia Cheng [http://www.amazon.com/gp/product/0465051715/ref=as_li_tl?ie=UTF8&camp=1789&creative=390957&creativeASIN=0465051715&linkCode=as2&tag=boffosocko-20&linkId=3QHVSGPXXWMTWGE2] which just came out in May in the US. It's a popular science text which gives some good overview of the subject and is the only book in that space at the moment to my knowledge.

I'll recommend that, if you're impatient, you take a peek at David Spivak's book Category Theory for the Sciences [http://www.amazon.com/gp/product/0262028131/ref=as_li_tl?ie=UTF8&camp=1789&creative=390957&creativeASIN=0262028131&linkCode=as2&tag=boffosocko-20&linkId=BW3G2IMA3JGCU2FC] which is currently one of the best introductory books on the market for those without more advanced background in mathematics. It was released last year by MIT Press and most of it can be found for free on the web - see the study site mentioned below for details. While it doesn't jump right in with heavy theorems/proofs the way most other popular texts in the area do, it does require a reasonable amount of mathematical sophistication, and it does provide a wealth of introductory material in chapters 1-4 on functions, sets, homomorphisms, isomorphisms, basic group theory, for those who don't have any background in set theory, basic topology, or abstract algebra.

As you're roughly in the same area I am, I'll mention that my interest in the topic was recently piqued by an article by Ilyas Khan: Category Theory – the bedrock of mathematics? [http://boffosocko.com/2015/04/30/category-theory-the-bedrock-of-mathematics-via-ilyas-khan/] It prompted me to drop my prior summer plans and create a category theory study group with a group of friends and many strangers. [see: Category Theory Study Group [http://cat.boffosocko.com/], which has a HUGE list of resources (including videos) in the area and is meant for students and self-study; feel free to join us if you'd like.]

As someone currently studying the topic, I will note that it isn't very difficult so far, and is relatively much easier than topics like advanced algebraic topology or Lie groups, so it could certainly be done at an advanced undergraduate level, but I'd certainly recommend diving into Spivak's book before any/many of the others which require a much higher level of mathematical sophistication typically required at the master's level or above. I would suggest that if you've done coursework in calculus and linear algebra and know most of the material in a book like A Primer of Abstract Mathematics (Classroom Resource Materials) by Robert B. Ash [http://www.amazon.com/gp/product/0883857081/ref=as_li_tl?ie=UTF8&camp=1789&creative=390957&creativeASIN=0883857081&linkCode=as2&tag=math01-20&linkId=J4TBWXWBEVTPHDU7http://www.amazon.com/gp/product/0883857081/ref=as_li_tl?ie=UTF8&camp=1789&creative=390957&creativeASIN=0883857081&linkCode=as2&tag=math01-20&linkId=J4TBWXWBEVTPHDU7], you should be able to tackle Spivak's book without too much difficulty. Having one or more of the other prerequisites I mentioned before would certainly help you move through the material much faster.

 
 

Some Hospitals are Marking up Prices More than 1,000 Percent

9 min read

I don't often (read: never) cut and paste press releases, but I've got an itching feeling that this is going to be BIG news over the next week or so, and thought I'd forward it along so you don't have to wait for the 5 second sound bite that this story is going to be diminished to. You'll be able to get it directly from the horse's mouth. It'll also give you time to write to your senators and congressmen as well as the growing list of presidential candidates entering the ring.  

The original research can be found in the current issue of the journal "Health Affairs"

“Extreme Markup: The 50 U.S. Hospitals with the Highest Charge-to-Cost Ratios” was written by Ge Bai and Gerard F. Anderson.

A brief synopsis from my friends at the Johns Hopkins Bloomberg School of Public Health follows:

The 50 hospitals in the United States with the highest markup of prices over their actual costs are charging out-of-network patients and the uninsured, as well as auto and workers’ compensation insurers, more than 10 times the costs allowed by Medicare, new research suggests. It’s a markup of more than 1,000 percent for the same medical services.

'What other industry can you think of that marks up their prices by 1,000 percent and remains in business?’

The findings, from Gerard F. Anderson of the Johns Hopkins Bloomberg School of Public Health and Ge Bai of Washington and Lee University, show that the combination of a lack of regulation of hospital charges in the United States and no market competition is leading to price-gouging that trickles down to nearly all consumers, whether they have health insurance or not, and plays a role in the rise of overall health spending. The report is published in the June issue of Health Affairs.

“There is no justification for these outrageous rates, but no one tells hospitals they can’t charge them,” says Anderson, a professor in the Bloomberg School’s Department of Health Policy and Management. “For the most part, there is no regulation of hospital rates and there are no market forces that force hospitals to lower their rates. They charge these prices simply because they can.”

For their study, Anderson and Bai analyzed the 2012 Medicare cost reports from the Centers for Medicare and Medicaid Services to determine a charge-to-cost ratio, an indicator of how much hospitals are marking up charges beyond what Medicare agrees to pay for those with its government-subsidized health insurance.

The 50 hospitals, they found, charged an average of more than 10 times the Medicare-allowed costs. They also found that the typical United States hospital charges were on average 3.4 times the Medicare-allowable cost in 2012. In other words, when the hospital incurs $100 of Medicare-allowable costs, the hospital charges $340. In one of the top 50 hospitals, that means a $1,000 charge.

Of the 50 hospitals with the highest price markups, 49 are for-profit hospitals and 46 are owned by for-profit health systems. One for-profit health system, Community Health Systems Inc., operates 25 of the 50 hospitals. Hospital Corp. of America operates more than one-quarter of them. While they are located in many states, 20 of the hospitals are in Florida.

“For-profit hospitals appear to be better players in this price-gouging game,” says Bai, an assistant professor of accounting at Washington & Lee University. “They represent only 30 percent of hospitals in the U.S., but account for 98 percent of the 50 hospitals with highest markups."

Many hospital patients don’t actually pay the “charge master” or full price. Along with government insurers, most private health insurers negotiate lower rates for their patients.

But 30 million uninsured Americans are likely to be charged the full rate, as are patients receiving out-of-network care and those receiving workers’ compensation or auto insurance benefits. As a result, uninsured patients, who are often the most vulnerable, face exceptionally high medical bills, often leading to personal bankruptcy, damaged credit scores or the avoidance of needed medical services.

The impact of overcharging extends beyond hospital patients. Notes Anderson: “The cost of workers’ compensation and auto insurance policies are higher in the states where hospital charges are unregulated because companies must pay those higher rates.”

In addition, privately insured in-network patients may also end up paying greater premiums due to hospitals' high markups, which are often used by hospitals as leverage to negotiate higher prices with private insurance companies. “Except for patients with government insurance, few consumers are immune from negative financial impacts caused by hospitals' high markups,” Bai says.

In Maryland and West Virginia, the state sets the rates that hospitals can charge for services. No federal law regulates them for all Americans.

“We as consumers are paying for this when hospitals charge 10 times what they should,” Anderson says. “What other industry can you think of that marks up the price of their product by 1,000 percent and remains in business?”

For the most part, the hospitals with the highest markups are not situated in pricey neighborhoods or big cities, where the market might explain the higher prices. The most expensive hospital is North Okaloosa Medical Center, located in the Florida Panhandle about an hour outside Pensacola. There, patients are charged 12.6 times more than Medicare allowable costs.

Anderson says changes are unlikely to drop to levels closer to costs allowed by Medicare unless state or federal officials decide to legislate a maximum markup that a hospital could charge a patient. He says states could choose to have their hospital rates set by a state agency as is done in Maryland and West Virginia, which guarantees that hospitals can’t gauge their patients.

He says that price transparency could also help only to a limited extent because people cannot bargain or comparative shop when they are sick. Most hospitals aren’t required to – and don’t – publicly share how much they charge for different procedures

“This system has the effect of charging the highest prices to the most vulnerable patients and those with the least market power,” Anderson says. “The result is a market failure.”

List of 50 Hospitals with Highest Charge-to-Cost Ratios, 2012:

1.         North Okaloosa Medical Center (FL)

2.         Carepoint Health-Bayonne Hospital (NJ)

3.         Bayfront Health Brooksville (FL)

4.         Paul B Hall Regional Medical Center (KY)

5.         Chestnut Hill Hospital (PA)

6.         Gadsden Regional Medical Center (AL)

7.         Heart of Florida Regional Medical Center (FL)

8.         Orange Park Medical Center (FL)

9.         Western Arizona Regional Medical Center (AZ)

10.       Oak Hill Hospital (FL)

11.       Texas General Hospital (TX)

12.       Fort Walton Beach Medical Center (FL)

13.       Easton Hospital (PA)

14.       Brookwood Medical Center (AL)

15.       National Park Medical Center (AR)

16.       St. Petersburg General Hospital (FL)

17.       Crozer Chester Medical Center (PA)

18.       Riverview Regional Medical Center (AL)

19.       Regional Hospital of Jackson (TN)

20.       Sebastian River Medical Center (FL)

21.       Brandywine Hospital (PA)

22.       Osceola Regional Medical Center (FL)

23.       Decatur Morgan Hospital - Parkway Campus (AL)

24.       Medical Center of Southeastern Oklahoma (OK)

25.       Gulf Coast Medical Center (FL)

26.       South Bay Hospital (FL)

27.       Fawcett Memorial Hospital (FL)

28.       North Florida Regional Medical Center (FL)

29.       Doctors Hospital of Manteca (CA)

30.       Doctors Medical Center (CA)

31.       Lawnwood Regional Medical Center & Heart Institute (FL)

32.       Lakeway Regional Hospital (TN)

33.       Brandon Regional Hospital (FL)

34.       Hahnemann University Hospital (PA)

35.       Phoenixville Hospital (PA)

36.       Stringfellow Memorial Hospital (AL)

37.       Lehigh Regional Medical Center (FL)

38.       Southside Regional Medical Center (VA)

39.       Twin Cities Hospital (FL)

40.       Olympia Medical Center (CA)

41.       Springs Memorial Hospital (SC)

42.       Regional Medical Center Bayonet Point (FL)

43.       Dallas Regional Medical Center (TX)

44.       Laredo Medical Center (TX)

45.       Bayfront Health Dade City (FL)

46.       Pottstown Memorial Medical Center (PA)

47.       Dyersburg Regional Medical Center (TN)

48.       South Texas Health System (TX)

49.       Kendall Regional Medical Center (FL)

50.       Lake Granbury Medical Center (TX)

 

SOURCE: Authors' analysis of Healthcare Cost Report Information System (HCRIS) computer files obtained from the Centers for Medicare and Medicaid Services for 2012, published in the appendix of the June 2015 issue of Health Affairs.

 

@JamesMcDonaId If using Twitter for research, you might consider some of these thoughts I wrote a while back http://stream.boffosocko.com/2015/some-brief-thoughts-for-a-scientific-link-blog-for-wbialekif

 

Stack Overflow Developer Survey 2015

Some interesting data on programmers/developers, pay, location, gender, satisfaction, etc/

 

‘Sleeping beauty’ papers slumber for decades #complexity

Interesting statistics on sleeping papers. There are some cool things going on here...